Domain _experience_ is what hiring managers look for. If there’s a high-paying job in some rarified field (say analytics, algo trading, low-latency..) then domain experience on the resume is the crucial factor. Many candidates can have strong tech background, and strong domain knowledge, but only those with “relevant experience” will get short-listed, or those with good recruiter connections.
Generic domain knowledge is very “thin”. You can pick it up by reading or over a few months on the job. Mostly jargons, and very little math. Hiring managers ask questions to verify such knowledge but it’s not hard to pass.